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Träfflista för sökning "WFRF:(JOHANSSON C) ;pers:(Johansson B);pers:(Larsson C)"

Search: WFRF:(JOHANSSON C) > Johansson B > Larsson C

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  • Sandén, B., et al. (author)
  • The significance of radiolucent zones surrounding pedicle screws : definition of screw loosening in spinal instrumentation
  • 2004
  • In: Journal of Bone and Joint Surgery. - 0301-620X .- 2044-5377. ; 86 B:3, s. 457-461
  • Journal article (peer-reviewed)abstract
    • We examined the radiographs from a prospective clinical study of fixation by pedicle screws and those from an experimental study in a sheep model. In the clinical study, instruments were removed from 21 patients after implantation for 11 to 16 months and the extraction torques of the screws were recorded. A structured protocol was used for the radiological examinations. In the experimental study, loaded pedicle screw instrumentations were implanted in the sheep for six or 12 weeks. After radiological examination the pull-out resistance and the histological characteristics were studied. In the clinical study, all screws with radiolucent zones had a significantly reduced mean extraction torque compared with screws without radiolucent zones (16 +/- 10 Ncm v 403 +/- 220 Ncm; p < 0.0001). In the experimental study the mean maximum pull-out resistance for the screws with radiolucent zones was significantly lower than for those with no radiolucency (243 +/- 156 N v2214 +/- 578 N; p = 0.0006) and the mean bone-to-screw contact was reduced for screws with zones compared with those without zones (8 +/- 9% v 55 +/- 29%; p = 0.0002). Our findings showed that all screws with radiolucent zones had low extraction torques or low pull-out resistance. A radiolucent zone is a good indicator of loosening of a pedicle screw.
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  • Pang, S. T., et al. (author)
  • Cytogenetic and expression profiles associated with transformation to androgen-resistant prostate cancer
  • 2006
  • In: The Prostate. - : Wiley. - 0270-4137 .- 1097-0045. ; 66:2, s. 157-172
  • Journal article (peer-reviewed)abstract
    • BACKGROUND. The mechanisms underlying the progression of prostate cancer to androgen-resistant cancer are still not fully understood. Here, we studied the genetic events associated with this transformation. METHODS. The androgen sensitive prostate cancer cells line LNCaP-FGC and its androgen resistant subline LNCaP-r were investigated using SKY, CGH, and cDNA microarray. RESULTS. Karyotypically, several additional chromosomal aberrations were seen in LNCaP-r as compared to the parental line. CGH also revealed unique net chromosomal alterations in LNCaP-r compared to LNCaP-FGC, including gain of 2p13-23, 2q21-32, and 13q and loss of 6p22-pter. cDNA microarray analysis identified several genes involved in DNA methylation, such as DNMT2, DNMT3a, and methyl-CpG binding domain protein 2 and 4 that were higher expressed in LNCaP-r. Interestingly, androgen responsiveness of LNCaP-r was restored after treated with DNA methyltransferase inhibitor. CONCLUSIONS. Our findings may serve as a basis for molecular dissection of the mechanisms involved in development of androgen resistant prostate cancer.
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  • Result 1-4 of 4

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